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Anatomic and Functional Imaging Techniques for Response Assessment in Oncology

From the Department of Radiology, Duke University Medical Center

Authors’ disclosures of potential conflicts of interest are found at the end of this article.

Address reprint requests to Daniel C. Sullivan, MD, Professor of Radiology; e-mail: daniel.sullivan{at}duke.edu

Overview: Combined positron emission tomography (PET)/computerized tomography (CT) scanners are widely available now in the United States, and integration of anatomic (volumetric) data from the CT component and functional data from the PET component is likely to increasingly become the norm for monitoring tumors in both clinical practice and clinical trials. Several variations of magnetic resonance imaging (MRI) technology are also maturing for tumor monitoring. Dynamic contrast-enhance-MRI is useful in phase I or II clinical trials, but its role in routine clinical practice is unclear. Diffusion-weighted magnetic resonance studies to date suggest considerable promise for this modality to become important for detection and monitoring of cancer in clinical practice.